Table 2.

Microbleeds and incident lacunes.

		Incident lacunes
	n/N	Model 1	Model 2	Model 3
No pre-existing microbleeds	8/608	Reference	Reference	Reference
Pre-existing microbleeds (all)	12/195	4.67 (1.84; 11.85)	4.25 (1.56; 11.60)	4.67 (1.59; 13.74)
Pre-existing strictly lobar	6/129	3.56 (1.18; 10.74)	3.27 (0.97; 11.00)	4.79 (1.46; 15.67)
Pre-existing deep or infratentorial	6/66	6.60 (2.17; 20.09)	6.10 (1.61; 23.14)	4.16 (0.96; 17.93)
No incident microbleeds	10/725	Reference	Reference	Reference
Incident microbleeds (all)	10/78	9.18 (3.61; 23.35)	6.28 (2.26; 17.47)	8.41 (2.82; 25.10)
Incident strictly lobar	4/49	5.60 (1.63; 19.30)	4.19 (1.03; 17.07)	7.75 (2.07; 28.98)
Incident deep or infratentorial	6/29	17.09 (5.60; 52.20)	10.43 (2.80; 38.77)	9.25 (2.17; 39.38)

Model 1: adjusted for age, sex, and scan interval.

Model 2: as model 1, additionally adjusted for blood pressures, total and HDL cholesterol, smoking, diabetes mellitus, lipid lowering medication, antihypertensive medication, and antiplatelet medication.

Model 3: as model 1, additionally adjusted for apolipoprotein E ε4 genotype.

Values represent odds ratios for incident lacunes in participants with pre-existing and incident microbleeds compared to no microbleeds.

Abbreviations: n= number of participants with incident lacunes; N= total number of participants.