FIG. 2.
Efficacy of WCK 771 in mouse cellulitis model. The results are shown as histograms of the reductions in viable counts per lesion at the end of therapy compared to the viable counts at the onset of treatment in the controls. Bars indicate standard deviations. MXF, moxifloxacin; VAN, vancomycin; LZD, linezolid. Values above the drug names indicate the dose (in milligrams per kilogram). Results are shown as the organism load reduction at the end of the study period compared with the load in the untreated controls at the start of treatment; results that are significantly different (P < 0.05) from those for the controls are indicated with an asterisk. (A) S. aureus Smith (ATCC 13709; MSSA) infection; treatment schedule, 1, 4, 24, and 27 h postinfection; (B) MRSA 5027 infection; treatment schedule, 1, 3, and 5 h postinfection; (C) MRSA 32 infection; treatment schedule, 1, 3, and 5 h postinfection.