TABLE 6.
Values of pharmacokinetic parameters for WCK 771 and other agents in mice
| Agenta | Route | AUC0-6 (μg · h/ml [SD]) | Cmax (μg/ml [SD]) | t1/2 (h [SD]) | Unbound fraction (%) in serumb |
|---|---|---|---|---|---|
| WCK 771 | s.c. | 23.02 (1.49) | 14.51 (3.47) | 0.47 (0.2) | 20 |
| Moxifloxacin | s.c. | 12.05 (0.89) | 9.49 (0.69) | 1.10 (0.15) | 50 |
| Trovafloxacin | s.c. | 34.50 (3.06) | 8.72 (1.81) | 1.85 (0.63) | 25 |
| Sparfloxacin | s.c. | 20.18 (2.44) | 6.65 (0.91) | 1.72 (0.41) | 55 |
| Ciprofloxacin | Oral | 7.36 (1.34) | 3.92 (0.18) | 0.90 (0.86) | 70 |
| Vancomycin | s.c. | 57.83 (5.26) | 65.84 (2.56) | 0.71 (0.09) | 60c |
| Linezolid | s.c. | 88.51 (14.57) | 48.16 (6.75) | 1.19 (0.20) | 70 |
a
Each agent was administered at a dose of 50 mg/kg.
b
Determined from published data (see Materials and Methods).
c
Very variable.