Table 5.
Cox proportional hazard univariate and multivariate analyses: risk factors vs. peritonitis and technique failure
| Univariate Cox proportional hazards | Multivariable Cox proportional hazards | |||
|---|---|---|---|---|
| Variable | Hazard ratio (95% Conf. Interval) |
P value | Hazard ratio (95% Conf. Interval) |
P value |
| Peritonitisd | ||||
| HIV | 2.41 (1.69–3.45) | <0.001 | 1.84 (1.07–3.16) | 0.027 |
| Race | 0.19 (0.06–0.57 | 0.003 | 0.54 (0.05–5.66) | 0.607 |
| Catheter insertion methoda | 1.86 (1.28–2.71) | 0.001 | 0.63 (0.28–1.42) | 0.269 |
| Catheter insertion siteb | 2.20 (1.45–3.33 | <0.001 | 2.17 (0.84–5.58) | 0.108 |
| Diabetes | 2.22 (1.35–3.66) | 0.002 | 2.09 (1.09–4.03) | 0.027 |
| BMI | 1.04 (1.00–1.08 | 0.033 | 1.01 (0.95–1.09) | 0.720 |
| Waist circumference | 1.02 (1.00–1.04) | 0.017 | 1.03 (0.99–1.06) | 0.151 |
| Baseline hemoglobin | 0.85 (0.77–0.94) | 0.002 | 1.02 (0.88–1.19) | 0.786 |
| Baseline albumin | 0.95 (0.93–0.98) | 0.001 | 0.98 (0.94–1.02) | 0.298 |
| Baseline CRP | 1.00 (1.00–1.01) | 0.004 | 1.00 (1.00–1.00) | 0.652 |
| Baseline CD4 count (cells/µL) | ||||
| HIV-negative | Reference | |||
| CD4 < 200 | 4.54 (2.35–8.76) | <0.001 | 3.28 (1.42–7.61) | 0.006 |
| CD4 200–350 | 2.61 (1.6–4.24) | <0.001 | 1.18 (0.66–2.12) | 0.577 |
| CD4 ≥ 350 | 2.10 (1.39–3.15) | <0.001 | 1.00 | |
| Residence | ||||
| City | Reference | |||
| Townshipc | 5.94 (2.17–16.25) | 0.001 | 5.56 (0.82–37.50) | 0.078 |
| Rural area | 6.07 (2.19–16.8) | 0.001 | 4.68 (0.70–31.07) | 0.110 |
| Technique failuree | ||||
| HIV | 1.42 (0.73–2.73) | 0.299 | 0.39 (0.14–1.11) | 0.077 |
| Peritonitis | 9.29 (2.84–30.36) | <0.001 | 14.47 (2.79–75.00) | 0.001 |
| Catheter insertion site | 2.33 (1.09–4.97) | 0.029 | 2.73 (0.49–15.21) | 0.252 |
| Catheter insertion method | 1.62 (0.79–3.30) | 0.185 | 0.69 (0.13–3.71) | 0.663 |
| Average hemoglobin | 0.72 (0.59–0.88) | 0.001 | 0.75 (0.59–0.95) | 0.016 |
| Average CRP | 1.02 (1.01–1.02) | <0.001 | 1.02 (1.01–1.03) | <0.001 |
BMI Body mass index, CD cluster of differentiation, CRP C-reactive protein, HIV human immunodeficiency virus
aCatheter insertion method- laparoscopic vs. percutaneous, bCatheter insertion site - Inkosi Albert Luthuli Central Hospital vs King Edward VIII Hospital, cSouth African Township refers to underdeveloped urban areas created under apartheid for non-white residents
dAdjusted for age, race, gender, smoking, diabetes, body mass index, waist circumference, baseline hemoglobin, baseline serum albumin, baseline C-reactive protein, primary residence, highest education level, employment, baseline CD4 count, Tenckhoff catheter insertion site, and Tenckhoff catheter insertion method (laparoscopic vs. percutaneous)
eAdjusted for HIV, peritonitis, age, gender, smoking, diabetes, body mass index, waist circumference, average hemoglobin, average C-reactive protein, average serum ferritin, primary residence, highest education level, employment, Tenckhoff catheter insertion site, and Tenckhoff catheter insertion method (laparoscopic vs. percutaneous)