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Development of TB infection in lungs (A) and spleens (B) of mice treated with anti-TB drugs. Mice were infected i.v. with 106 CFU of M. tuberculosis H37Rv, and at day 7 chemotherapy was initiated. Differences between CFU for INH (25 mg) and RIF (20 mg) and for EMB (100 mg) are highly significant in lung (P < 0.001) (A) and in spleen (P < 0.05) (B).
