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. 2017 Feb 3;9:13. doi: 10.1186/s13148-017-0314-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Distribution of differentially methylated probes (DMPs). a Heatmap of top 2000 DMPs. Hierarchical clustering showing separate grouping of DMPs for OSCC and adjacent normal tissue. b Genomic localisation of hypermethylated and hypomethylated probes at the CpG islands (CGIs), shore, shelves, and open sea. c Average methylation across the CGIs, shores, and shelves for hypo- and hypermethylated CGIs