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. 2017 Feb 3;9:13. doi: 10.1186/s13148-017-0314-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Validation of HumanMethylation450K bead chip data. The upper panel shows the avergae β values, and the lower panel shows the clonal validation by sequencing the bisulfite-converted products of a LXN and b PTPN22 promoters. The filled circle in the lower panel represents the methylated, and the open circle represents the unmethylated CpGs. Gene expression of c LXN and d PTPN22 showed significant differential expression between OSCC and adjacent normal tissues, correlating with methylation status