FIG. 4.

(A) Efficacy of delayed combinatorial treatment against pulmonary tularemia. BALB/c animals (six mice per group) were challenged i.n. with 10³ CFU of F. tularensis subsp. novicida. At various intervals after challenge, the mice were treated i.n. with a combination of 100 μg of gentamicin and 100 ng of soluble recombinant IL-12. As a control some animals were treated with PBS alone. (B) The animals were weighed and monitored daily for survival. The differences in the rates of survival between mice treated with gentamicin and IL-12 at 8 and 24 h, 24 and 36 h, and 48 and 60 h and mice treated with PBS alone were significant (P < 0.001).