FIG. 5.

(A) Effects of substitution of IFN-γ for IL-12 in the combinatorial therapy against pulmonary tularemia. BALB/c animals (six mice per group) were challenged i.n. with 10³ CFU of F. tularensis subsp. novicida. At 8 and 24 h after infection, the mice were treated i.n. with 100 μg of gentamicin and 100 ng of soluble recombinant IFN-γ or 100 μg of gentamicin alone. (B) The animals were weighed and monitored daily for survival. The differences in the rates of survival between mice treated with gentamicin and IFN-γ and mice treated with gentamicin alone were significant (P < 0.001).