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. Author manuscript; available in PMC: 2018 Feb 6.
Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2016 Apr 9;73:87–103. doi: 10.1016/j.pnpbp.2016.03.010

Fig. 1.

Fig. 1

Overview of miRNA biogenesis and its interaction with FMRP. RNA polymerase transcribes the miRNA genes, and Drosha processes the resulting pri-miRNAs. Then, pre-miRNAs are exported into the cytoplasm and are further processed by Dicer. Mature miRNAs are loaded into the RISC, which in turns binds to complementary sequences on 3′UTRs of target mRNAs. According to an alternative hypothesis, FMRP binds to some mRNAs, and miRNA-RISC can interact with FMRP-mRNA complex, thereby leading to translational inhibition.