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The effect of SNPs on miRNA-mediated regulation of gene expression. SNPs in different steps of miRNA biogenesis exert diverse effects on the regulation of gene expression. (A) SNPs in miRNA genes can alter miRNA expression. (B) SNPs in target mRNAs also affect miRNA function by altering miRNA-target interaction. (C) SNPs in miRNA machinery genes affect the entire transcriptome that is subject to miRNA-mediated regulation.
