Table 2. . Matrix effect of four different types of human tissue homogenate on pegcantratinib (100 ng/ml) and internal standard (1μg/ml).

Tissue type	Pegcantratinib (MF)	CT340 (MF)	Ratio
Skin with anagen follicles	1.05	1.05	1.00
Cylindroma and spiradenoma	0.97	0.96	1.01
Cylindroma only	1.07	1.05	1.02
Spiradenoma only:	0.92	1.01	0.91
– Mean	1.00	1.02	0.99
– SD	0.07	0.04	0.05
– CV (%)	7.1	3.9	5.0

CV: Coefficient of variation; MF: Matrix factor.