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Mean plasma drug concentration-time profiles on day 1 (first dose) and day 5 (last dose) following 6-h i.v. infusions of 175 mg of BB-83698/kg for a total of 5 days. Following 6-h infusions of 175 mg of BB-83698/kg, two serial plasma samples were obtained at times up to 24 h on day 1 after the first dose (open circles), and two more were obtained on day 5 after the last dose (open squares). Plasma samples were analyzed by a validated LC/MS/MS method with appropriate QCs.
