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PK parameters for rats following i.v. administration of BB-83698 over 28 days
| Time point (day) | Sexb |
Cmax (μg/ml) at indicated dose (mg/kg/day)
|
AUC0-last (μg · h/ml) at indicated dose (mg/kg/day)
|
||||
|---|---|---|---|---|---|---|---|
| 10 | 22 | 50 | 10 | 22 | 50 | ||
| 1 | M | 10.5 | 26.4 | 51.1 | 8.0 | 17.5 | 53.1 |
| F | 10.0 | 25.8 | 66.0 | 10.8 | 33.0 | 95.5 | |
| 28a | M | 12.4 | 42.6 | 41.0 | 6.9 | 23.7 | 99.7 |
| F | 15.3 | 40.1 | 64.9 | 8.5 | 23.3 | 80.3 | |
Day 14 for animals receiving dose of 50 mg/kg/day.
M, male; F, Female.
