TABLE 4.
PK parameters and clinical observations for dogs following i.v. infusion of BB-83698
| Dose (mg/kg/day) | Sexa | No. of dogs | Infusion time (h) | Clinical observation(s) | AUC∞ (μg · hr/ml) | Cmax (μg/ml) |
|---|---|---|---|---|---|---|
| 50 | M and F | 2 | 1 | None | 74 | 29 |
| 75 | M and F | 3 | 1 | Vomiting, unsteadiness, tremor, buckling of hind limbs | 127-157 | 52-55 |
| 75 | F | 1 | 2 | None | 118 | 34 |
| 100 | M | 1 | 1 | Vomiting, restlessness, convulsion at end | 178 | 60 |
| 150 | M and F | 2 | 6 | Lip licking | 213, 169b | 30, 23 |
| 175 | M and F | 2 | 6c | |||
| Day 1 | Occasional vomiting, decreased activity | 228, 214 | 35, 34 | |||
| Day 5 | Occasional vomiting, decreased activity | 159, 147 | 25, 23 |
a
M, male; F, Female.
b
Values separated by commas are for male and female dogs, respectively.
c
For the 175 mg/kg/day dose, the infusion was done for 6 h/day for 5 days.