TABLE 5.
Dose (mg) | Cmax (μg/ml) | AUC0-24 (μg · h/ml) | AUC∞ (μg · h/ml) | t1/2 (h) | CL (ml/min) | Vss (liters) |
---|---|---|---|---|---|---|
10 | 0.5 ± 0.1 | 0.3 ± 0.1 | 0.4 ± 0.1 | 4.8 ± 0.7 | 520.6 ± 139.4 | 93.2 ± 20.7 |
25 | 1.2 ± 0.3 | 1.3 ± 0.2 | 1.3 ± 0.2 | 5.0 ± 0.8 | 335.1 ± 70.4 | 68.0 ± 14.7 |
50 | 2.7 ± 0.6 | 3.6 ± 0.7 | 3.7 ± 0.7 | 6.0 ± 1.8 | 233.5 ± 43.4 | 56.7 ± 21.9 |
100 | 5.3 ± 1.4 | 9.5 ± 3.0 | 10.3 ± 3.0 | 10.1 ± 5.8 | 173.3 ± 46.6 | 69.8 ± 34.3 |
200 | 9.6 ± 2.1 | 21.8 ± 6.7 | 26.6 ± 7.9 | 15.4 ± 11.8 | 135.4 ± 38.1 | 106.2 ± 73.0 |
325 | 15.6 ± 3.4 | 32.8 ± 8.1 | 41.3 ± 10.1 | 16.7 ± 10.6 | 141.5 ± 46.8 | 106.1 ± 67.4 |
400 | 18.5 ± 3.6 | 36.0 ± 7.6 | 39.2 ± 7.5 | 8.7 ± 7.5 | 175.9 ± 33.3 | 70.1 ± 38.5 |
475 | 19.3 ± 4.0 | 38.9 ± 8.9 | 45.8 ± 12.0 | 8.5 ± 4.8 | 188.5 ± 68.3 | 87.8 ± 39.9 |
Values are given in means±standard deviations.