TABLE 1.
MICs of β-lactams for E. aerogenes LOR and CF23.04 isolates and for recombinant E. coli DH10B(pBK-TEM-121), DH10B(pBK-TEM-24), and DH10B
| β-Lactama | MIC (μg/ml) for the following isolateb:
|
||||
|---|---|---|---|---|---|
| E. aerogenes LOR | E. coli DH10B(pBK-TEM-121) | E. aerogenes CF24.03 | E. coli DH10B(pBK-TEM-24) | E. coli DH10B | |
| Amoxicillin | >512 | >512 | >512 | >512 | 2 |
| Amoxicillin-CLA | 16 | 32 | 512 | 4 | 2 |
| Ticarcillin | >512 | >512 | >512 | 512 | 1 |
| Ticarcillin-CLA | 128 | 256 | 128 | 32 | 1 |
| Piperacillin | 32 | 64 | 128 | 128 | 1 |
| Piperacillin-TZB | 4 | 8 | 16 | 8 | 1 |
| Cephalothin | 8 | 16 | >512 | >512 | 4 |
| Cefoxitin | 4 | 2 | 128 | 2 | 2 |
| Cefuroxime | 8 | 8 | >512 | 256 | 0.5 |
| Ceftriaxone | <0.06 | <0.06 | 32 | 8 | <0.06 |
| Cefotaxime | <0.06 | <0.06 | 32 | 8 | <0.06 |
| Ceftazidime | 128 | 256 | 512 | 256 | <0.06 |
| Aztreonam | 8 | 16 | 512 | 256 | 0.06 |
| Cefepime | 2 | 4 | 4 | 4 | 0.06 |
| Cefpirome | 2 | 4 | 4 | 4 | 0.06 |
| Imipenem | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 |
a
CLA, clavulanic acid at 2 μg/ml; TZB, tazobactam at 4 μg/ml.
b
E. aerogenes isolate LOR produced β-lactamase TEM-121, whereas E. aerogenes CF24.03 produced TEM-24 and AmpC-type β-lactamases. Recombinant E. coli DH10B(pBK-TEM-121) and E. coli DH10B(pBK-TEM-24) produced β-lactamases TEM-121 and TEM-24, respectively.