Table 4.
Associations of site-specific High BMD loss (>0.5% annualized) (visit 1 to visit 3) to hematopoietic cell types at visit 3, N=2571
Anemia | Low Platelets | WBC subtype | ||||||
---|---|---|---|---|---|---|---|---|
Neutrophils | lymphocytes | monocytes | ||||||
Low | High | Low | high | Low | high | |||
Femoral neck | ||||||||
Age & Site Adj. | 1.93 (1.40, 2.67) | 1.23 (0.96, 1.57) | 0.99 (0.81, 1.23) | 1.20 (0.97, 1.48) | 1.49 (1.21, 1.84) | 0.86 (0.69, 1.06) | 1.12 (0.91, 1.38) | 0.92 (0.74, 1.13) |
MTV adj. | 1.79 (1.28, 2.49) | 1.17 (0.91, 1.50) | 0.97 (0.78, 1.20) | 1.16 (0.93, 1.43) | 1.49 (1.21, 1.84) | 0.88 (0.71, 1.09) | 1.06 (0.85, 1.31) | 0.87 (0.70, 1.08) |
Total hip | ||||||||
Age & Site Adj. | 2.37 (1.70, 3.30) | 1.23 (0.95, 1.58) | 0.98 (0.79, 1.22) | 1.40 (1.13, 1.72) | 1.38 (1.12, 1.71) | 0.86 (0.69, 1.07) | 1.38 (1.11, 1.70) | 1.12 (0.90, 1.39) |
MTV adj. | 2.10 (1.49, 2.95) | 1.14 (0.88, 1.48) | 0.96 (0.76, 1.20) | 1.34 (1.08, 1.68) | 1.36 (1.09, 1.70) | 0.87 (0.69, 1.09) | 1.29 (1.04, 1.61) | 1.05 (0.84, 1.31) |
Lumbar Spine | ||||||||
Age & Site Adj. | 1.23 (0.80, 1.91) | 0.69 (0.47, 1.01) | 1.02 (0.76, 1.36) | 1.22 (0.92, 1.61) | 1.37 (1.04, 1.80) | 1.00 (0.74, 1.35) | 1.18 (0.89, 1.56) | 1.48 (1.11, 1.97) |
MTV adj. | 1.18 (0.75, 1.84) | 0.67 (0.45, 0.98) | 0.96 (0.71, 1.29) | 1.23 (0.92, 1.64) | 1.30 (0.99, 1.71) | 1.00 (0.74, 1.36) | 1.10 (0.83, 1.46) | 1.43 (1.06, 1.91) |
MTV: Adjusted for age, site, BMI, smoking status, alcohol use, physical activity, history of cancer, self-reported health, corticosteroid use, and thiazide use.