Table 1. Table of clinic-based and patient-reported outcomes.

	Assessment name	Acronym	Characteristics	Score range and direction
A	Expanded Disability Status Scale	EDSS	Criterion standard for MS Disability assessment	0–10 (Higher number = greater disability)
	Timed 25-foot walk	T25FW	Measures the time it takes a person to walk 25 feet Good reliability, reproducibility and strong associations of gait velocity with the EDSS have been reported	Greater times indicate slower walking speed and greater disability
	Timed Up and Go	TUG	Measures time taken to rise from a chair, walk for 3 m, turn around, walk back to the chair and sit down again Associations with balance, walking ability, and fall risk in MS	Greater times indicate worse balance and walking ability, and higher fall risk
	2-minute walk	2MW	Measures the distance walked (meters) in 2 min It is a validated, shorter alternative to the 6-minute walk test for measuring endurance	Shorter distances indicate less endurance
B	12-item MultipleSclerosis Walking Scale	MSWS-12	12 item questionnaire Assesses the impact of MS on walking ability High reliability, validity and internal consistency	12–60 (Higher score = greater self-reported impact of MS)
	Pain Effects Scale	PES	Assesses ways in which pain and unpleasant sensations interfere with mood, ability to walk or move, sleep, work, recreation, and enjoyment of life in persons with MS. Pain is reported in more than 50% of people with MS, and may be a limiting factor in physical activity participation	6–30 (Higher scores indicate greater pain)
	Bladder Control Scale	BLCS	Four-item questionnaire Assesses the extent to which bladder dysfunction impacts daily living	0–22 (Higher scores = greater bladder control issues)
	Bowel Control Scale	BWCS	Five-item questionnaire Assesses the extent to which bowel dysfunction impacts daily living	0–26 (Higher scores = greater bowel control issues)
	Modified Fatigue Impact Scale, 5-item version	MFIS-5	Assesses the impact of cognitive, physical functioning and psychosocial aspects of fatigue on daily life	0–20 (Higher scores = more impact from fatigue)
	Abbreviated mental health inventory	MHI-5	Assesses depression, anxiety, positive and negative affect and behavioral control Depression (affecting [33% of people with MS) has been linked with apathy and has the potential to affect physical activity levels	5–30 (Higher scores = greater impact on emotional functioning)