Table 3.
Demographic data | Entire cohort | Progressive MS | Relapsing MS | |
---|---|---|---|---|
a | ||||
Total N (% of cohort) | 99 | 38 (38%) | 61 (62%) | |
Women (% of MS subtype) | 63 (64%) | 20 (53%) | 43 (71%) | |
Men (% of MS subtype) | 36 (36%) | 18 (47%) | 18 (29%) | |
Age (years) | ||||
Mean (SD) | 50.1 (13.8) | 57.7 (9.1) | 45.4 (14.2) | |
Disease duration (years) | ||||
Median (interquartile range 25–75%) | 13.0 (6.0–21.0) | 16.0 (9.0–21.0) | 9.0 (4.0–21.0) | |
EDSS | ||||
Mean (range) | 4.1 (0.0–6.5) | 5.5 (3.0–6.5) | 3.2 (0.0–6.5) | |
Steps per day | ||||
Average (SD) | 5478 (3507) | 3809 (2104) | 6477 (3707) | |
Minimum–maximumA | 533–18,649 | 533–8396 | 1129–18,649 | |
RangeB | 326–28,074 | 326–15,118 | 336–28,074 | |
| ||||
Correlation and regressionstatistics | Outcomemeasure | Univariate model:Spearman's q | Multivariate model: adjusted R2, (e) | |
| ||||
b | ||||
Clinic-based | T25FW | −0.66d | 0.38d | |
TUG | −0.68d | 0.40d | ||
2MW | 0.69d | 0.43d | ||
Patient-reported | MSWS-12 | −0.66d | 0.37d | |
MFIS-5 | −0.41c | 0.17c | ||
PES | −0.32c | 0.09b | ||
BLCS | −0.39b | 0.10a | ||
BWCS | −0.22a | 0.07a | ||
MHI-5 | −0.02a | −0.01a |
In general, clinic-based performance measures displayed greater correlations with step count than patient-reported symptomatic outcomes, even in adjusted analyses. Significance, p values:
not statistically significant
p = 0.05
p 0.01
p 0.001
generalized linear model: adjusting for age, sex, disease subtype
MS multiple sclerosis, SD standard deviation, EDSS Kurtzke Expanded Disability Status Scale, T25FW timed 25-foot walk, TUG timed up and go, 2MW 2-minute walk, MSWS-12 12-item MS Walking Scale, MFIS-5 Modified Fatigue Index (5 item version), PES Pain Effects Scale, BLCS Bladder Control Scale, BWCS Bowel Control Scale, MHI-5 Mental Health Inventory (5 item version)
Average steps per day, over 4 weeks
Total steps per day, per participant