Table 2.
Comparison of UNOS-DGF and DGF48h as predictors of 12-month eGFR
| 12-month Outcome | UNOS-DGF | DGF48h | ||||||
|
No n=345 |
Yes n=215 |
Unadjusted Association (95% CI) * |
Adjusted Association (95% CI) ** |
No n=230 |
Yes n=330 |
Unadjusted Association (95% CI) * |
Adjusted Association (95% CI) ** |
|
| eGFR, ml/min/1.73m2 | 60±22 | 48±22 | −11.9 (−15.6, −8.2) | −7.3 (−10.9, −3.6) | 64±22 | 50±21 | −13.2 (−16.9, −9.5) | −7.4 (−11.0, −3.8) |
| eGFR <30 ml/min/1.73m2 | 27 (8) | 38 (18) | 2.3 (1.4, 3.6) | 1.9 (1.2, 3.1) | 12 (5) | 53 (16) | 3.1 (1.7, 5.6) | 2.1 (1.1, 3.7) |
| Acute Rejection | 41 (12) | 25 (12) | 1.0 (0.6, 1.6) | 1.0 (0.6, 1.7) | 23 (10) | 43 (13) | 1.3 (0.8, 2.1) | 1.4 (0.9, 2.4) |
| Death-Censored Graft Failure |
6 (2) | 17 (8) | 4.5 (1.8, 11.3) | 4.7 (1.6, 13.9) | 4 (2) | 19 (6) | 3.3 (1.1, 9.5) | 2.2 (0.7, 6.3) |
| Recipient Death | 7 (2) | 7 (3) | 1.6 (0.6, 4.5) | 1.4 (0.4, 5.7) | 3 (1) | 11 (3) | 2.5 (0.7, 9.0) | 2.1 (0.5, 8.0) |
|
Sensitivity Analyses (after removing 37 recipients with graft failure or death) | ||||||||
| 12-month Outcome | UNOS-DGF | DGF48h | ||||||
|
No n=332 |
Yes n=191 |
Unadjusted Association (95% CI) * |
Adjusted Association (95% CI) ** |
No n=223 |
Yes n=300 |
Unadjusted Association (95% CI) * |
Adjusted Association (95% CI) ** |
|
| eGFR, ml/min/1.73m2 | 60±21 | 52±19 | −8.2 (−11.7, −4.7) | −3.7 (−7.1, −0.3) | 65±20 | 52±19 | −12.2 (−15.6, −8.7) | −7.1 (−10.5, −3.8) |
| eGFR <30 ml/min/1.73m2 | 21 (6) | 18 (9) | 1.5 (0.8, 2.7) | 1.2 (0.7, 2.2) | 7 (3) | 32 (11) | 3.4 (1.5, 7.6) | 2.5 (1.1, 5.4) |
| Acute Rejection | 38 (11) | 22 12) | 1.0 (0.6, 1.7) | 1.0 (0.6, 1.7) | 21 (9) | 39 (13) | 1.4 (0.8, 2.3) | 1.5 (0.9, 2.6) |
United Network for Organ Sharing-defined delayed graft function (UNOS-DGF) is any dialysis in the first posttransplant week. DGF48h is delayed graft function defined as a serum creatinine reduction of <25% in the first 48 h or >1 dialysis session in the first posttransplant week. Values are mean ± standard deviation, n (%), or measure of association (95% confidence interval) as indicated.
Unadjusted associations with continuous eGFR tested via mixed effects linear regression and with dichotomous eGFR <30 ml/min/1.73m2 via modified Poisson regression
Same regressions as above adjusted for the following donor variables: age, circulatory death (rather than brain death), black race, hypertension, diabetes, height, weight, stroke as cause of death, and terminal serum creatinine; and the following transplant/recipient variables: cold ischemia time, age, black race, gender, previous kidney transplant, diabetes as the cause of end stage renal disease, number of human leukocyte antigen mismatches, body mass index, duration (vintage) of dialysis before transplant, and percent panel reactive antibody.