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Effect of treatment with CSP2 on pneumococcal sepsis. Two groups of CD1 outbred mice (n = 20) were injected i.v. with 106 CFU of wild-type strain TIGR4. While one group served as untreated controls (filled squares), the other group (open squares) was treated i.v. with CSP2 at 1.3 μg per mouse (corresponding to about 1 μg/ml of blood) at time zero and 24 h after challenge (both of which are indicated by arrows).
