TABLE 2.
Stability study of 10 μM [3H]NHC (1,000 dpm/pmol) in monkey and human whole blood
Time (h) | % Nucleoside in:
|
|||||
---|---|---|---|---|---|---|
Monkey blood
|
Human blood
|
|||||
Cytidine | NHC | Uridine | Cytidine | NHC | Uridine | |
0 | 0 | 100.0 | 0 | 0 | 100 | 0 |
0.08 | 0 | 99.0 | 1.0 | |||
0.16 | 0.3 | 91.7 | 8.02 | |||
1 | 0.5 | 85.0 | 14.5 | 0 | 95.3 | 4.7 |
2 | 0.0 | 65.2 | 34.9 | |||
4 | 0.6 | 49.2 | 50.2 | 0 | 92.0 | 8.0 |
24 | 10.2 | 25.6 | 64.2 | 7.7 | 39.9 | 52.4 |
t1/2 | 0.90 | 3.89 | 4.93 | 17.90 | 6.87 |