TABLE 3.
Sequences of NC/P1 and P1/P6 protease cleavage sites in clones with and without L23I
| Identification | Description | Position 23a | Drug resistance mutation(s) | Sequence change(s)b
|
|
|---|---|---|---|---|---|
| NC/pl (RQANFLGK) | pl/p6 (PGNFLQSR) | ||||
| 1277 | Clone with L23I | I | 82I | RQANFLGK | PGNFLQSR |
| 4485 | Clone 3 | WT | 46I, 53L, 54V, 84V, 90M | RQANFLGR | PGNFVQNR |
| 4485 | Clone 6 | I | 46I, 53L, 54V, 84V, 90M | RQANFLGR | PGNFVQNR |
| 4733 | Clone 3 | WT | 46L, 54V, 82A, 84V, 90M | RQVNFLGK | PGNFLQNR |
| 4733 | Clone 1 | I | 46L, 54V, 82A, 84V, 90M | RQVNFLGK | PGNFLQNR |
a
WT, wild type.
b
Boldface indicates differences from the consensus subtype B sequence.