Table 3.
Genes overexpressed in highly aggressive ovarian cancer cell lines
| Gene ID | Ratioa | Gene ID | Ratioa | Gene ID | Ratio |
|---|---|---|---|---|---|
| Bcat1 | 12.6 | Nusap1 | 3.45 | Bag2 | 2.33 |
| Gprc5c | 9.02 | Mum1l1 | 3.39 | Fam110a | 2.32 |
| Fscn1 | 7.64 | Trip13 | 3.38 | Phlda1 | 2.32 |
| 2810025M15Rik | 7.00 | E2f7 | 3.35 | Speg | 2.32 |
| Fstl1 | 6.65 | Ammecr1 | 3.29 | Skp2 | 2.28 |
| Nasp | 6.63 | 4930547N16Rik | 3.26 | Bok | 2.27 |
| Fam149a | 6.40 | Gadd45g | 3.25 | Flt1 | 2.25 |
| BC004728 | 6.24 | Sec16b | 3.11 | Tinagl1 | 2.25 |
| Cyp1b1 | 5.82 | Incenp | 3.10 | Trim16 | 2.24 |
| Aldh3a1 | 5.43 | Sh3kbp1 | 3.04 | Ntn4 | 2.23 |
| Prim1 | 5.43 | Hells | 3.03 | Pdlim2 | 2.23 |
| Dlg7 (Dlgap5) | 5.31 | Emp1 | 2.98 | Naaa | 2.19 |
| Vldlr | 5.29 | Rad18 | 2.98 | Elk3 | 2.18 |
| Ppp1r12b | 5.28 | C79407 | 2.97 | Tbc1d1 | 2.17 |
| Tanc2 | 4.93 | Lbh | 2.93 | Cd97 | 2.16 |
| Kntc1 | 4.66 | Traip | 2.91 | Ggt6 | 2.15 |
| Scn5a | 4.54 | Ccrn4l | 2.86 | Ifrd1 | 2.15 |
| Ripk3 | 4.47 | Sema3a | 2.83 | Slk | 2.15 |
| Car12 | 4.42 | Angptl4 | 2.79 | Afap1l2 | 2.15 |
| Fignl1 | 4.41 | Itgb3 | 2.76 | Apobec3 | 2.14 |
| Hopx | 4.41 | Erdr1 | 2.70 | Pgm2 | 2.13 |
| Sgol2 | 4.23 | Spp1 | 2.70 | Dpy19l3 | 2.12 |
| Rad51ap1 | 4.22 | Hmga2 | 2.66 | Nup155 | 2.12 |
| Uhrf1 | 4.19 | Atad5 | 2.65 | 6230416J20Rik | 2.11 |
| Sprr1a | 4.14 | Bmper | 2.64 | Nans | 2.11 |
| Rtn2 | 4.01 | Csdc2 | 2.63 | Asap1 | 2.10 |
| Slc16a3 | 4.01 | Gpsm2 | 2.63 | Hip1 | 2.08 |
| Pde5a | 3.96 | Gsta3 | 2.62 | Arf6 | 2.06 |
| Plk4 | 3.96 | Rbl1 | 2.58 | Lrrc8c | 2.06 |
| Sema5a | 3.90 | Gm71 | 2.57 | Ppil1 | 2.05 |
| Ncapg | 3.88 | Itgb5 | 2.53 | Zdhhc2 | 2.03 |
| Diap3 | 3.81 | G2e3 | 2.49 | 1700113i22rik | 2.02 |
| Ppic | 3.66 | Suz12 | 2.48 | Gats | 2.01 |
| Pole | 3.63 | Tfrc | 2.39 | Hnrnpa1 | 2.01 |
| Tesc | 3.63 | Med1 | 2.35 | Tmem184b | 2.01 |
| Cdca2 | 3.62 | Myc | 2.35 | ||
| Rad54l | 3.62 | Sema3e | 2.35 |
The ratio was calculated with the genes’ intensity of highly aggressive cell lines over moderately aggressive cell lines. Genes’ intensity of different cell lines obtained from Affymetrix was analyzed by GeneSifter. After global normalization, the ratio was generated with the average normalized intensity of highly aggressive cells lines and moderately aggressive cell lines. A minimum of twofold change (P<0.05) was used as the standards for selecting genes of interest. In some ratio, we added parentheses which contained the digits. These digits are the mean of intensity in the relevant genes obtained from microarray data. These relevant genes were involved in cell cycle, DNA metabolic process, and/or apoptosis and cell death and displayed in Table 8