Table 7.

Function enrichment analysis for the genes overexpressed in highly aggressive cell lines

Category	Term/name	Gene counta	Fold enrichment	P value	Benjamini corrected P value
BP	GO:0007049~cell cycle	15	4.83	1.55E-06	9.95E-04
BP	GO:0012501~programmed cell death	10	4.16	5.52E-04	2.92E-02
BP	GO:0006259~DNA metabolic process	12	5.15	8.00E-06	4.57E-03
BP	GO:0022403~cell cycle phase	11	6.60	4.92E-06	1.58E-03
BP	GO:0000279~M phase	10	6.96	1.09E-05	2.34E-03
BP	GO:0022402~cell cycle process	11	5.51	2.38E-05	3.81E-03
BP	GO:0000278~mitotic cell cycle	9	7.26	2.81E-05	3.61E-03
BP	GO:0000087~M phase of mitotic cell cycle	8	8.12	5.04E-05	4.62E-03
BP	GO:0007067~mitosis	7	7.26	3.68E-04	2.92E-02
BP	GO:0000280~nuclear division	7	7.26	3.68E-04	2.92E-02
BP	GO:0048285~organelle fission	7	7.00	4.46E-04	3.14E-02
BP	GO:0006915~apoptosis	10	4.24	4.88E-04	3.09E-02
BP	GO:0051301~cell division	8	5.61	4.95E-04	2.85E-02
BP	GO:0006281~DNA repair	7	6.21	8.37E-04	4.04E-02
BP	GO:0008219~cell death	10	3.88	9.07E-04	4.08E-02
BP	GO:0016265~death	10	3.79	1.07E-03	4.48E-02
CC	GO:0044454~nuclear chromosome part	5	11.04	1.00E-03	3.57E-02
CC	GO:0005819~spindle	5	10.43	1.24E-03	3.53E-02
CC	GO:0000775~chromosome, centromeric region	5	10.24	1.32E-03	3.14E-02
CC	GO:0000792~heterochromatin	4	17.83	1.37E-03	2.80E-02
CC	GO:0044427~chromosomal part	9	6.43	6.02E-05	8.69E-03
CC	GO:0000228~nuclear chromosome	6	11.27	1.69E-04	1.22E-02
CC	GO:0005694~chromosome	9	5.41	2.00E-04	9.60E-03

Genes that were overexpressed in highly aggressive ovarian cancer cell lines were selected and analyzed by David v6.7. Benjamini adjusted P value was smaller than 0.05

BP biological process, CC cellular component

^aGene numbers were involved in each term/name