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Metabolic pathways of thalidomide (A) and 5-n-butyl-pyrazolo[1,5-a]pyrimidine (B). Proposed formation of the glutathione conjugate (A) is modified from Chowdhury et al.43. Proposed mechanism for a putative quinone imine metabolite and conjugate formation at the 6-position (B) is taken from Kuribayashi et al.50
