TABLE 1.
Activities of HCV-371 against HCV NS5B polymerases from different isolates of genotypes 1a, 1b, 3a, and 4
| Genotype and enzyme isolate | HCV-371 IC50 ± SDa (μM) | Amino acid sequence divergence from genotype 1b BK
|
|
|---|---|---|---|
| % | No. of changes | ||
| Genotype 1b | |||
| BK | 0.3 ± 0.1 (n = 51) | ||
| 4a | 0.4 ± 0.3 (n = 14) | 3.4 | 19 |
| 320-10-3 | 0.5 ± 0.3 (n = 8) | 4.4 | 25 |
| 320-3-1 | 0.4 ± 0.2 (n = 12) | 4.6 | 27 |
| BB7 | 0.4 ± 0.2 (n = 15) | 3.7 | 22 |
| 320-2-1 | 0.5 ± 0.2 (n = 14) | 4.2 | 25 |
| J4 | 0.4 ± 0.1 (n = 6) | 4.7 | 28 |
| FC 1-20 | 0.5 ± 0.6 (n = 17) | 4.7 | 27 |
| Genotype 1a | |||
| 9606 | 4.8 ± 2.7 (n = 14) | 11.5 | 67 |
| A5 | 1.4 ± 0.8 (n = 15) | 11.5 | 68 |
| 207-248 | 0.6 ± 0.2 (n = 16) | 11.3 | 66 |
| 207-221 | 0.7 ± 0.4 (n = 15) | 11.4 | 64 |
| 207-247 | 1.0 ± 0.5 (n = 16) | 11.8 | 69 |
| Genotype 3a | |||
| 167-A1 | 1.8 ± 1.3 (n = 22) | 24.7 | 144 |
| Genotype 4 | 17.8 ± 8.0 (n = 3) | 21.5 | 126 |
a
Inhibitory activities are expressed as the mean IC50 ± standard deviation. n, number of determinations.