TABLE 2.
Antiviral specificity of HCV-371
| Virus | Family | Classification | HCV-371 EC50 ± SDa (μM) |
|---|---|---|---|
| HCV | Flaviviridae | Positive single-stranded RNA | |
| 1b replicon | 4.8 ± 0.5b | ||
| 1a replicon | 6.1 ± 1.9b | ||
| SARS-CoV | Coronaviridae | Positive single-stranded RNA | >100c |
| RSV | Paramyxoviridae | Negative single-stranded RNA | >80c |
| LCMV | Arenaviridae | Ambisense RNA | >100d |
| CMV | Herpesviridae | Double-stranded DNA | >100d |
| HSV-1 | Herpesviridae | Double-stranded DNA | >100d |
a
Each value represents the mean from at least two determinations.
b
Values are based on the measurement of the HCV RNA.
c
EC50s were assessed by cytopathic effect protection in infected cells.
d
EC50s were determined by virus-specific ELISA.