TABLE 3.
Effect of HCV-371 on mammalian cell metabolic functions
| Cell line | Growing condition | Species of origin | Cell type and source | CC50 ± SDc (μM) |
|---|---|---|---|---|
| Huh-7 | Dividing and stationarya,b | Human | Liver epithelial cells | >160 |
| MT4 | Dividing and stationarya | Human | Lymphocytes | >160 |
| HFF | Dividing and stationarya | Human | Foreskin fibroblasts | >160 |
| Vero | Dividing and stationarya | African green monkey | Kidney epithelial cells | >160 |
| CHO-K12 | Dividingb | Hamster | Ovary epithelial cells | 63 ± 6.4 |
| C6 | Dividingb | Rat | Brain fibroblasts | 80 ± 7.8 |
a
Measured by ATP production.
b
Measured by a standard MTT bioreduction assay.
c
Inhibitory activities are expressed as mean CC50. Each reported value represents the mean of results from at least two independent determinations.