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. 2017 Jan 22;2017:4024672. doi: 10.1155/2017/4024672

Figure 1.

Figure 1

The impact of parenteral Vit C treatment on the 72-hour survival rate of septic mice and sepsis-induced MODS. The 72-hour survival rate of WT mice and Gulo−/− mice was improved on administration of 200 mg/Kg parenteral Vit C twice after CLP (a). Parenteral Vit C improved the biomarkers of liver (b and c), renal (d), respiratory (e and f), and circulatory (g) function in CLP-exposed WT mice and Vit C deficient Gulo−/− mice. The survival rate was analyzed by Kaplan-Meier via the log-rank test, n = 50 per group. WT (CLP) versus WT (CLP + Vit C), p < 0.01. Gulo−/− (CLP) versus Gulo−/− (CLP + Vit C), p < 0.01. WT (CLP) versus Gulo−/− (CLP), p < 0.05. Data were represented as mean ± standard deviation (SD) and analyzed by software SPSS 17.0 with one-way ANOVA, n = 4 per group, ∗p < 0.05 or ∗∗p < 0.01.