. Author manuscript; available in PMC: 2017 Feb 5.

Published in final edited form as: Mol Genet Metab. 2015 Oct 23;116(4):305–313. doi: 10.1016/j.ymgme.2015.10.008

Table 3.

Metabolic syndrome-associated loci showing Bonferroni-corrected significant association with individual components of the MetS and related cardiometabolic traits^a

Gene	MetS^b GWAS SNP (chr: position)	Replication trait	Replicated SNP	Position	Alleles	A1^c freq	P-value	Data set
MBNL1	rs146816516 (chr3:152262078)	Systolic BP	rs76204242	152291018	A,C	0.98	3.74E-05	A
		Body Mass Index	rs116815255	152192393	T,A	0.98	1.29E-05	B
		Body Mass Index	rs145202083	152193084	C,A	0.98	1.32E-05	B
		Body Mass Index	rs150947994	152195940	T,A	0.98	1.25E-05	B
		Body Mass Index	rs114991118	152199365	T,A	0.98	1.16E-05	B
		Body Mass Index	rs184693776	152201330	C,T	0.98	1.07E-05	B
		Body Mass Index	rs114284899	152203823	G,T	0.98	1.32E-05	B
		Body Mass Index	rs192244039	152209252	C,T	0.98	1.17E-05	B
		Body Mass Index	rs183566325	152221527	G,T	0.98	2.66E-05	B
		Body Mass Index	rs6804557	152334938	C,A	0.98	1.44E-05	B
		Body Mass Index	rs6773118	152339917	C,T	0.98	1.05E-05	B
KSR2	rs7964157 (chr12:117982220)	Systolic BP	rs78683574	117980191	T,A	0.89	1.39E-05	A
		Systolic BP	rs7964157	117982220	C,T	0.70	3.56E-05	A
		Diastolic BP	rs7964157	117982220	C,T	0.70	3.56E-05	A
		Systolic BP	rs1501635	117973298	T,C	0.60	2.70E-05	B
		Systolic BP	rs78683574	117980191	T,A	0.89	1.35E-05	B
		Triglycerides	rs11610896	117973915	A,G	0.64	1.70E-05	B
		Triglycerides	rs7964157	117982220	C,T	0.70	9.92E-06	B
		Triglycerides	rs11610896	117973915	A,G	0.64	1.14E-05	C
		Triglycerides	rs7964157	117982220	C,T	0.70	2.06E-05	C
EDEM1-GRM7	rs149307971 (chr3:5854876)	HDL cholesterol	rs1377212	5767686	G,C	0.27	7.20E-06	A
		HDL cholesterol	rs1377212	5767686	G,C	0.27	1.54E-05	B
		HDL cholesterol	rs1377212	5767686	G,C	0.27	1.71E-05	C
		HDL cholesterol	rs116357511	5769812	G,T	0.87	2.16E-05	B
		HDL cholesterol	rs116357511	5769812	G,T	0.87	2.11E-05	C
CTNNA3	rs77244975 (chr10:69207975)	Waist circumference	rs188455459	69273893	C,T	0.98	1.40E-05	B

SNPs within 100kb distance from the variants showing genome-wide significant association with MetS were tested for association with components of MetS in the discovery datasets. Here we reported those showing Bonferroni-corrected (0.05/number of SNPs tested in the respective locus) significant association.

MetS: the metabolic syndrome based on definition of the National Cholesterol Education Program (NCEP).

A1 freq: frequency of the first of the two alleles listed under the ‘Alleles’ column in the West African discovery dataset.

Position: base-pair position in NCBI Build 37 coordinates

A: Full dataset (602 cases from Ghana and Nigeria (AF1), 825 AF1 controls)

B: 33.3% tails of cMetS (402 AF1 cases, 550 AF1 controls)

C: 25% tails of cMetS (310 AF1 cases, 405 AF1 controls)

cMetS: continuous metabolic syndrome score based on the sum of standardized residuals of the metabolic syndrome component traits.