TABLE 1.
Mean values of pharmacokinetic parameters for telithromycin following administration of a single oral dose of 800 mga
| Compartment | AUC0-8 (mg · h/liter) | AUC0-24 (mg · h/liter) | Cmax (mg/L) | Tmax (min) | AUC0-8 tissue/ AUC0-8 total plasma | AUC0-8 tissue/ AUC0-8 free plasma | t1/2β (min) | V/F (liters) | CL/F (liters/min) |
|---|---|---|---|---|---|---|---|---|---|
| Plasma (total) | 4.1 ± 1.5 (1.9-6.3) | 6.1 ± 2.4 (3.9-9.2) | 1.2 ± 0.5 (0.6-2.3) | 164 ± 35 (120-240) | ND | ND | 185 ± 75 (105-284) | 634 ± 274 (311-1,029) | 1.5 ± 0.8 (0.8-3.1) |
| Plasma (free) | 0.5 ± 0.2 (0.3-0.9) | 0.7 ± 0.3 (0.3-1.3) | 0.1 ± 0.1 (0.08-0.25) | 164 ± 35 (120-200) | ND | ND | 160 ± 25 (55-346) | ND | ND |
| Subcutis | 0.9 ± 0.6 (0.3-1.8) | 1.6 ± 1.0 (0.5-3.4) | 0.2 ± 0.1 (0.05-0.4) | 306 ± 36 (240-360) | 0.2 ± 0.2 (0.1-0.7) | 2.1 ± 1.6 (0.4-5.5) | 169 ± 77 (104-353) | ND | ND |
| Muscle | 0.6 ± 0.3 (0.1-1) | 0.8 ± 0.5 (0.1-1.7) | 0.2 ± 0.1 (0.03-0.4) | 243 ± 63 (140-360) | 0.2 ± 0.1 (0.1-0.3) | 1.5 ± 0.9 (0.4-3.2) | 176 ± 104 (68-395) | ND | ND |
a
Values represent mean ± SDs (ranges). Abbreviations: Cmax, maximum concentration of drug in plasma; Tmax, time to maximum concentration of drug in plasma; ND, not determined.