Table 2.

Inclusion and exclusion criteria.

Inclusion Criteria

18–64 years of age history of recurrent major depressive episodes with winter-type seasonal pattern by DSM-IV-TR criteria, based on the SCID-I and our supplemental graphic diagnostic tool history of euthymia during August 2010 free of medical illness and not pregnant, as determined by detailed history and physical examination including blood and urine chemistries and thyroid function tests

Exclusion Criteria

history of concurrent psychiatric illness that would preclude compliance with the protocol and ability to complete the study safely active suicidal or homicidal ideation variable psychiatric symptoms such as rapid cycling or severe premenstrual syndrome that could interfere with accurate assessment of the treatment effect history of substance abuse/dependence with less than one year remission GAF < 50 light treatment in the previous month previous failure to respond significantly to an adequate course of light treatment pregnant or lactating any antidepressant or mood-stabilizing medications or remedies (even if taken for non-psychiatric indications), including selective serotonin-reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, tricyclic antidepressants, antipsychotics, lithium, benzodiazepines, monoamine oxidase inhibitors, tryptophan, St. John’s wort nightwork or other habitual alteration of sleep/wake cycle medical conditions that affect mood or produce hallmark symptoms of mood disorder use of photosensitizing medications (amiodarone, benoxaprofen, chlorpromazine, demeclocycline, fleroxacin, nalidixic acid, ofloxacin, piroxicam, porfimer, psoralens, quinidine, temoporfin) or remedies (St. John’s wort, melatonin) macular degeneration or cataract of a level that would significantly affect transmission or processing of light through either eye (LOCS3 # 4) history of eye trauma and/or use of medication such as tetracycline or oral isoretinoin (Accutane), that would affect the safety of light exposure treatment or complaints of eyestrain or abnormal tearing with computer use of up to 30 min at a time

DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders, 4^th edition, text revision; GAF: Global Assessment of Functioning; LOCS3: Lens Opacities Classification System III; SCID-I: Structured Clinical Interview for DSM IV Axis I Disorders.