Table 3.
Top 10 enriched pathway terms of DEGs sorted by p value (ascending).
| GO term | Ontology source | Term p value corrected with Bonferroni step down | Genes cluster #1 | Genes cluster #2 |
|---|---|---|---|---|
| Biological oxidations | REACTOME_10.02.2016 | 520.0E − 9 | [Aoc1, BC021614, Cyp17a1, Cyp27b1, Cyp2d22, Cyp2d26, Cyp4a14, Ephx1, Gm10639, Gm3776, Gsto1, Maoa, Maob] | [Ces2c, Cndp2, Cyp2a4, Cyp51, Cyp7b1] |
| Bile acid and bile salt metabolism | REACTOME_10.02.2016 | 120.0E − 6 | [Abcc3, Gm6614] | [Akr1c14, Akr1c18, Amacr, Cyp7b1, Slco1a1] |
| Steroid hormone biosynthesis | KEGG_10.02.2016 | 440.0E − 6 | [Cyp17a1, Cyp2d22, Cyp2d26, Ugt2b34] | [Akr1c18, Cyp7b1, Hsd17b2, Ugt2b37, Ugt2b38] |
| Bile secretion | KEGG_10.02.2016 | 680.0E − 6 | [Abcb1a, Abcb1b, Abcc3, Abcc4, Ephx1, Slc5a1] | [Slc22a7, Slco1a1] |
| Metabolism of fat-soluble vitamins | REACTOME_10.02.2016 | 770.0E − 6 | [Apoe, Cyp27b1, Gc, Ttr] | [Akr1c14, Akr1c18, Ubiad1] |
| Metapathway biotransformation | WikiPathways_10.02.2016 | 3.5E − 3 | [Cyp17a1, Cyp27b1, Ephx1, Gm3776, Gsta4, Gsto1] | [Chst11, Cyp51, Cyp7b1, Fmo5] |
| Glutathione conjugation | REACTOME_10.02.2016 | 6.2E − 3 | [BC021614, Gm10639, Gm3776, Gsto1] | [Cndp2] |
| Generation of second messenger molecules | REACTOME_10.02.2016 | 93.0E − 3 | [Cd3e, Cd3g, Grap2] | |
| Peroxisomal lipid metabolism | REACTOME_10.02.2016 | 93.0E − 3 | [Agps, Amacr, Crot] | |
| Cyclin A/B1 associated events during G2/M transition | REACTOME_10.02.2016 | 93.0E − 3 | [Ccnb2, Plk1, Wee1] |