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CD-19 designs for leukemia.
| MSKCC | NCI | UPenn | |
|---|---|---|---|
| Design | CD28-19-28z | CD28-FMC63-28Z | 4-1BB-CD19-BB |
| Vector | Retrovirus | Retrovirus | Lentivirus |
| Expression | Approx. 30 days | Approx. 30 days | >4 years |
| CR in ALL | 90% | 80% | 90% |
| CR in CLL | 0/8 | 4/14 | |
| PR in CLL | 0/8 | 4/14 | |
| OOR in CLL | 0.00% | 57% |
CR: complete response, ALL: acute lymphocytic leukemia, CLL: chronic lymphocytic leukemia, PR: partial response, and ORR: overall response rate.
