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. 2017 Feb 6;8:59. doi: 10.3389/fpls.2017.00059

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Copyright © 2017 Rissel, Heym, Thor, Brandt, Wessjohann and Peiter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparisons of active sites and inhibitor binding in crystal structures of animal ADP ribosyltransferase proteins, AtRCD1, and AtSRO1. Left panels show crystal structures of HsPARP10, GgPARP1, and HsPARP14 with co-crystallized inhibitors 3-aminobenzamide (3-AB), 4-amino-1,8-naphthalimide (4-ANI), and 6-(5H)-phenanthridinone (PHE), respectively. Center and right panels show homology models of AtRCD1 and AtSRO1 with bound inhibitors. Despite different amino acid motifs, the inhibitors can be bound in the same manner as in the template structures.