FIGURE 4.

Therapeutic efficacy of ciprofloxacin, CFI or DRCFI treatment in a mouse model of inhalational Y. pestis infection. BALB/c mice (n = 10/group) were challenged via the aerosol route with approximately 3 × 10⁴ CFU Y. pestis CO92 and treated 42 h post-challenge with 30 mg/kg of intraperitoneal (IP) ciprofloxacin, 300 μl IP PBS, aerosolized empty liposomes (2.8 mg/kg lipid), 1 mg/kg lung dose of aerosolized CFI or DRCFI (2.7 and 3.2 mg/kg lipid, respectively). Graphs show the survival of mice following (A) 1 dose of therapy and (B) 3 days of therapy. All treatments improved survival compared to PBS or empty liposome treatment (P < 0.001). Asterisks indicate significant differences in survival, ^∗ for p = 0.016, ns indicates there were no significant differences (P < 0.05).