Table 2.
Intracerebral pathogenicity index scores and MDT values for parental rLaSota and rSG10 and their polymerase-associated protein gene chimeras.
| Virus | ICPI scorea | MDT (h)b |
|---|---|---|
| rLaSota | 0.00 | >120 |
| rLaSGNP | 0.00 | >120 |
| rLaSGP | 0.00 | >120 |
| rLaSGL | 0.00 | >120 |
| rLaSGNPP | 0.34ˆ** | >120 |
| rLaSGNPL | 0.14ˆ* | >120 |
| rLaSGPL | 0.12ˆ* | >120 |
| rLaSGNPPL | 0.63ˆ*** | >120 |
| rSG10 | 1.86 | 57 |
| rSGLaNP | 1.78 | 72∗∗ |
| rSGLaP | 1.89 | 52 |
| rSGLaL | 1.68ˆ** | 83∗∗∗ |
| rSGLaNPP | 1.90 | 58 |
| rSGLaNPL | 1.48ˆ*** | 86∗∗∗ |
| rSGLaPL | 1.40ˆ*** | 84∗∗∗ |
| rSGLaNPPL | 1.32ˆ*** | 89∗∗∗ |
aPathotype definitions by ICPI: virulent strains, 1.50–2.00; moderately virulent strains, 0.70–1.50; avirulent strains, 0.00–0.70. bPathotype definitions by MDT: virulent strains, <60 h; moderately virulent strains, 60–90 h; avirulent strains, >90 h. Asterisks indicate the statistical significance of the ICPI score and MDT of a chimeric virus compared to the parental virus of that group. P-values were calculated based on a two-tailed, unpaired t test (95% confidence levels). ∗p = 0.01–0.05, significant; ∗∗p = 0.001–0.01, very significant; ∗∗∗p = 0.0001–0.001, extremely significant.