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. 2017 Feb 6;8:36. doi: 10.3389/fphar.2017.00036

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Copyright © 2017 Karagueuzian, Pezhouman, Angelini and Olcese.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Suppression of aconitine-induced ventricular tachycardia/ventricular fibrillation (VT/VF) with the specific I_Na-L blocker, GS967(1 μM) and reversal of its effect on washout. (A) Aconitine-induced VF, which converts to monomorphic VT 3 min after arterial perfusion of GS967 (B) and to sinus rhythm 7 min after GS967 (C). Washout of GS967 with drug-free Tyrode's perfusion causes the reemergence of monomorphic VT that degenerates to VF 8 min after GS967 washout (D). The reintroduction of GS967 in the perfusate suppresses the VF by first converting it to monomorphic VT and then to sinus rhythm (E). Note the marked shortening of the action potential duration after GS967-induced conversion of the monomorphic VT to sinus rhythm despite lengthening of the cycle length (C, E) (from Pezhouman et al., 2014b).