TABLE 4.
Parameter estimates and percent standard error of the mean for the final model
| Parameter | Final estimate of population mean | % SEM | Final estimate of magnitude of interindividual variability (%CV) | % SEM |
|---|---|---|---|---|
| ka (l/h) | 2.41 | 27.3 | ||
| CL/Fa coefficient (ml/min) | 83.4 | 1.9 | 25.5 | 15.0 |
| V/Fb coefficient (liters) | 67.1 | 1.9 | 18.8 | 31.0 |
| WTKG-V power | 0.635 | 8.8 | ||
| IBW-CL slope | 0.764 | 15.8 | ||
| CRCL-CL power | 0.436 | 13.0 | ||
| Additive shift in V for males | 17.7 | 10.1 | ||
| Additive shift in CL for obesity | 10.9 | 25.3 | ||
| Age-CL slope | 0.301 | 33.9 | ||
| Proportional shift in CL for concomitant pseudoephedrine use | −0.144 | 37.4 | ||
| Residual variability (%CV) | 27.6 | 11.4 |
a
The typical value of the apparent CL/F for nonobese patients at the median values of age (49.5 years), CrCL, (86.9 ml/min), and IBW (64.2 kg).
b
The typical value of the apparent volume of distribution for female patients at the median WTKG (79.3 kg).