TABLE 7.
Selected covariate results from univariate logistic regression analysis of clinical cure
| Covariate |
P value
|
|
|---|---|---|
| S. pneumoniae (n = 96) | H. influenzae, H. parainfluenzae, M. catarrhalis (n = 216) | |
| Patient factors | ||
| Age (yr) | 0.4193 | 0.9316 |
| Gender | 0.5409 | 0.5877 |
| CrCL (ml/min) | 0.3881 | 0.7028 |
| WTKG | 0.6313 | 0.6365 |
| Disease covariates | ||
| Condition treated | 0.6412 | 0.3467 |
| MIC | —a | 0.8954 |
| Exposure measurements | ||
| fu AUC0-24 | 0.8531 | 0.0309 |
| fu Cmax | 0.9246 | 0.1465 |
| fu AUC0-24/MIC ratio | 0.0510 | 0.8350 |
| fu Cmax/MIC ratio | 0.0530 | 0.7605 |
a
—, MIC was excluded from the clinical cure analysis of the S. pneumoniae patient population since for 94% of the patients the value was either 0.03 or 0.06 μg/ml.