TABLE 8.
Selected covariate results from univariate logistic regression analysis of bacteriologic eradication
| Covariate |
P value
|
|
|---|---|---|
| S. pneumoniae (n = 91) | H. influenzae, H. parainfluenzae, M. catarrhalis (n = 207) | |
| Patient factors | ||
| Age (yr) | 0.5145 | 0.7102 |
| Gender | 0.6007 | 0.5678 |
| CrCL (ml/min) | 0.3667 | 0.3578 |
| WTKG | 0.8430 | 0.5747 |
| Disease covariates | ||
| Condition treated | 0.5536 | 0.7855 |
| MIC | —a | 0.1922 |
| Exposure measures | ||
| fu AUC0-24 | 0.7994 | 0.0077 |
| fu Cmax | 0.8258 | 0.0749 |
| fu AUC0-24/MIC ratio | 0.1557 | 0.9439 |
| fu Cmax/MIC ratio | 0.2560 | 0.8366 |
a
—, MIC was excluded from the bacteriologic eradication analysis of the S. pneumoniae patient population since for 95% of the patients the value was either 0.03 or 0.06 μg/ml.