TABLE 9.

Estimated population mean PK parameters at selected covariate values

Renal function categoryb	Gender	Obesity	n	Covariate Valuea				PK parameter value
				CrCL (ml/min)	IBW (kg)	Age (yr)	WTKG (kg)	AUCc (μg · h/ml)	Cmax (mg/liter)
Moderate (30-50 ml/min)	Male	Nonobese	22	44	71	77	73	88.3	6.12
		Obese	5	45	66	75	92	80.8	5.52
	Female	Nonobese	15	43	50	74	54	115	8.69
		Obese	17	45	45	67	73	104	7.49
Mild (51-80 ml/min)	Male	Nonobese	67	67	69	67	75	79.9	5.77
		Obese	19	65	67	60	100	74.3	5.18
	Female	Nonobese	61	71	52	49	60	99.7	7.83
		Obese	52	68	52	55	81	85.3	6.58
Normal (>80 ml/min)	Male	Nonobese	133	107	77	41	80	67.7	5.24
		Obese	41	105	76	46	116	60.9	4.51
	Female	Nonobese	84	96	58	35	61	85.5	7.29
		Obese	61	99	59	42	99	71.7	5.67

^aThe covariate values represent the median patient covariates for each renal function category, subset by gender and obesity, rounded to the nearest integer.

^bThere was an insufficient number of patients (n = 3) with severe renal function (15 to 29 ml/min) to perform this comparison.

^cCL (milliliters per minute) = (400 mg·10³)/AUC (micrograms per hour per milliliter)·60.