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. 2004 Dec;48(12):4766–4777. doi: 10.1128/AAC.48.12.4766-4777.2004

TABLE 9.

Estimated population mean PK parameters at selected covariate values

Renal function categoryb Gender Obesity n Covariate Valuea
PK parameter value
CrCL (ml/min) IBW (kg) Age (yr) WTKG (kg) AUCc (μg · h/ml) Cmax (mg/liter)
Moderate (30-50 ml/min) Male Nonobese 22 44 71 77 73 88.3 6.12
Obese 5 45 66 75 92 80.8 5.52
Female Nonobese 15 43 50 74 54 115 8.69
Obese 17 45 45 67 73 104 7.49
Mild (51-80 ml/min) Male Nonobese 67 67 69 67 75 79.9 5.77
Obese 19 65 67 60 100 74.3 5.18
Female Nonobese 61 71 52 49 60 99.7 7.83
Obese 52 68 52 55 81 85.3 6.58
Normal (>80 ml/min) Male Nonobese 133 107 77 41 80 67.7 5.24
Obese 41 105 76 46 116 60.9 4.51
Female Nonobese 84 96 58 35 61 85.5 7.29
Obese 61 99 59 42 99 71.7 5.67
a

The covariate values represent the median patient covariates for each renal function category, subset by gender and obesity, rounded to the nearest integer.

b

There was an insufficient number of patients (n = 3) with severe renal function (15 to 29 ml/min) to perform this comparison.

c

CL (milliliters per minute) = (400 mg·103)/AUC (micrograms per hour per milliliter)·60.