Table 1.

Treatment-induced changes in the interregional molecular relation of serotonin transporter (SERT) availability in patients with major depressive disorder (MDD).

Before treatment compared to first treatment (PET 1–PET 2)
ACC	Midbrain (+0.45), pallidum (+0.61), putamen (+0.34)
Hippocampus	Amygdala (+0.20), insula (+0.37), pallidum (+0.47)
Insula	Pallidum (+0.56)

Changes are based on baseline Positron emission tomography (PET 1) compared to SERT availability after a single oral dose of a selective serotonin reuptake inhibitor (SSRI; PET 2) (values in parenthesis are differences in Spearman’s ρ; p < 0.05, uncorrected).