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Deoxycorticosterone (DOC) response to naloxone (375 µg/kg) administration. The DOC response is summarized across the experimental phases by area under the curve (A). DOC concentrations for each timepoint sampled during baseline (B), induction (C), and self-administration (D) are shown. Symbols represent significant differences when compared to t = 15 (b) or t = 30 (c); see main text for specific p-values. Animals are uniquely colored. **p < 0.001, ***p < 0.0001.
