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. 2017 Feb 6;8:13. doi: 10.3389/fendo.2017.00013

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Copyright © 2017 Fridmanis, Roga and Klovins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Formation of functionally active adrenocorticotropic hormone receptor (ACTHR). The functional form of ACTHR is a hetero-hexameric structure formed from two molecules of ACTHR and four molecules of MRAP1. The antiparallel dimer of MRAP1 is formed within the endoplasmic reticulum, where it couples to one molecule of ACTHR. Afterward, this complex is transported to the Golgi where it “dimerizes,” thus forming the hetero-hexameric functional ACTHR (128). Symbols representing ACTHR and MRAP1 were selected to highlight the protein secondary structure. The depicted intermolecular interactions are therefore general and do not reflect the actual situation in detail.