Table 1. Frequencies of common recurrent gene mutations in adults with AML or MDS.

Mutated gene	Frequency in AML1	Frequency in MDS104, 105
NPM1	25–35%	2%
DNMT3A	18–22%	8%
FLT3-ITD	~20%	0–2%
TET2	7–25%	11–26%
IDH2	8–19%	~5%
AXLS1	5–17%	11–15%
RUNX1	5–15%	4–14%
NRAS	~15%	3–6%
IDH1	7–14%	3%

Abbreviations: AML, acute myeloid leukemia; MDS, myelodysplastic syndromes.