Table 3. Toxicity outcomes—tests are by Wilcoxon rank-sum test except for *(log-rank test).

Toxicity	DA		DClo		P-value
	% grade 3–4	Mean grade	% grade 3–4	Mean grade
Course 1
Nausea	5%	0.8	10%	1.0	0.01
Oral	3%	0.7	2%	0.7	0.4
Diarrhoea	12%	1.1	8%	1.0	0.12
Cardiac	7%	0.4	5%	0.3	0.3
Liver AST	6%	0.6	6%	0.5	0.6
Liver ALT	4%	0.6	6%	0.7	0.3
Bilirubin	7%	0.8	5%	0.7	0.04
Median days to neutrophil recovery	20		24		<0.0001*
Median days to platelet recovery	21		24		<0.0001*
Mean blood units	11.0		9.5		0.0002
Mean platelet units	12.9		9.8		<0.0001
Mean days antibiotics	19.7		16.7		<0.0001
Mean hospitalisation days	33.8		31.4		<0.0001
Course 2
Nausea	4%	0.7	7%	0.9	0.004
Oral	1%	0.4	1%	0.4	0.9
Diarrhoea	4%	0.6	9%	0.7	0.19
Cardiac	2%	0.1	2%	0.2	0.7
Liver AST	1%	0.2	4%	0.4	0.06
Liver ALT	3%	0.4	2%	0.6	0.004
Bilirubin	3%	0.5	5%	0.4	0.4
Median days to neutrophil recovery	20		21		0.2*
Median days to platelet recovery	25		24		0.3*
Mean blood units	6.3		6.4		0.9
Mean platelet units	6.0		5.7		0.03
Mean days antibiotics	9.4		9.6		0.6
Mean hospitalisation days	25.0		23.4		0.01